Udinese ended Sampdoria’s unbeaten Serie A start with a 4-0 victory at Friuli, where Blucerchiati midfielder Edgar Barreto was sent off.
The home side had been on the back of a three-match losing streak, but went ahead on 27 minutes through a penalty from Rodrigo De Paul.
Sampdoria, who beat AC Milan last time out, then found themselves down to 10 men after Barreto collected his second caution just before the break.
Udinese doubled their lead after 66 minutes from another penalty, this time Maxi Lopez converting low into the bottom corner.
The Argentina forward made it 3-0 after 85 minutes with a clever chip over the goalkeeper, before Seko Fofana wrapped things up deep into stoppage time with a third spot-kick, the Ivorian having been bundled over in the area.
In Saturday’s late kick-off, Rodrigo Palacio scored against his old club to give Bologna a 1-0 win at struggling Genoa.
The veteran Argentine forward, who started his Serie A career with the Rossoblu, made the crucial breakthrough in the 73rd minute when he muscled his way into the right side of the penalty area before dispatching a low shot into the far corner.
Bologna goalkeeper Antonio Mirante, though, had to be at his best to deny Genoa a share of the spoils with some fine saves before Rossoblu striker Andrey Galabinov saw his late effort come back off the woodwork.
A fifth defeat in six Serie A matches leaves Genoa second from bottom with just two points as the pressure mounts on coach Ivan Juric.